期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 87, 期 2, 页码 1230-1239出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02565
关键词
-
资金
- SERB, DST, Govt. of India [EMR/2016/003706]
- IIT Patna
In this study, we have developed an efficient method for the synthesis of alkyl, benzyl, and phenyl selenoethers of aminopyrazoles and aminouracils using visible light and Rose Bengal as an organophotocatalyst. The reaction proceeded smoothly, providing the desired compounds in good to very good yields. This method offers several advantages including metal-free conditions, high yields, use of an organic photocatalyst, and broad substrate scope.
Herein, we report an efficient methodology for the synthesis of alkyl, benzyl, and phenyl selenoethers of aminopyrazoles and aminouracils by C(sp(2))-H functionalization in the presence of visible light and Rose Bengal as an organophotocatalyst. The reaction of amino pyrazole/iosothiazole/isoxazole or amino uracils with 0.5 equivalent of diphenyl/dibenzyl/diethyl diselenides in the presence of visible light in acetonitrile medium and a catalytic amount of Rose Bengal provided the corresponding phenyl, benzyl, or ethyl selenoethers in good to very good yields. We have also utilized some of the selenylated aminopyrazoles for the preparation of pyrazole-fused dihydropyrimidines tethered with arylselenoethers by a catalyst-free one-pot three-component reaction. The notable features of this methodology are metal-free reaction conditions, good to very good yields, use of an organic photocatalyst, and wide substrate scope; it is also applicable to gram-scale synthesis and provides selenoethers of medicinally important heterocycles such amio-pyrazole, isoxazole, isothiazole, and uracils.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据