期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 87, 期 5, 页码 3577-3585出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c03131
关键词
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资金
- National Natural Science Foundation of China [22102072, 22171137, 22025104, 21972064]
- Natural Science Foundation of Jiangsu Province [BK20200765]
A general, scalable, and convenient photochemical process is reported for the synthesis of various distal oxygenated nitriles from less-strained ketoxime esters. This method allows for one-step introductions of ether and cyano groups, eliminating the need for toxic cyanide reagents. The reaction is applicable to a wide range of cycloketoxime esters and linear ketoxime esters, providing structurally diverse ring-opening products under simple and mild conditions.
We report a general, scalable, and convenient photochemical process for diversities of distal oxygenated nitriles from corresponding less-strained ketoxime esters allowing one-step introductions of ether and cyano groups, which avoids the utilization of toxic cyanide reagents. A wide range of ketoxime esters involving five-membered to eight-membered cycloketoxime esters and linear ketoxime esters participate smoothly under operately simple and mild conditions, affording structurally variable ring-opening products.
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