Synthesis of Furo[2,3-e][1,4]diazepin-3-one Derivatives through Tandem Cyclization/[4+3] Annulation Reactions

A variety of furo[2,3-e][1,4]diazepin-3-one derivatives were facilely synthesized through one-pot tandem cyclization/ [4 + 3] annulation reactions between enynamides and alpha-bromohydroxa- mates. The reactions proceeded efficiently at room temperature, and various functional groups were well tolerated. The obtained furo [2,3- e][1,4]diazepin-3(2H)-ones containing a 7-membered dinitrogen- fused ring might be of biological and medicinal value. The products could be further derived using convenient procedures.

Automated summary

A variety of furo[2,3-e][1,4]diazepin-3-one derivatives were successfully synthesized through a simple method, showing potential biological and medicinal value.