One-Pot Synthesis of Substituted 2-Amino Isonicotinic Acids: Reminiscent of the Guareschi-Thorpe Condensation

This work describes a concise manner to make a wide variety of mono-or disubstituted 2-amino isonicotinic acids via the corresponding 2,4-dioxo-carboxylic acid ethyl esters and ethyl 3-amino-3-iminopropionate hydrochloride. The reaction likely proceeds through an in situ decarboxylation process and is reminiscent of the Guareschi-Thorpe Condensation.

Automated summary

This work presents a concise method for synthesizing a wide range of mono- or disubstituted 2-amino isonicotinic acids using 2,4-dioxo-carboxylic acid ethyl esters and ethyl 3-amino-3-iminopropionate hydrochloride. The reaction likely involves an in situ decarboxylation process and bears resemblance to the Guareschi-Thorpe Condensation.