期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 24, 页码 18067-18080出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02343
关键词
-
资金
- Council of Scientific and Industrial Research (CSIR), MHRD, Government of India [02(0460)/21/EMR-II]
A novel and efficient method for synthesizing quinazolinones via copper-catalyzed one-pot synthesis has been developed using urea, hydrazine hydrate, and atmospheric oxygen as reagents, showing good adaptability and a wide range of substrates.
A novel, efficient, and atom-economical approach for the construction of quinazolinones from 2-nitrobenzaldehydes has been unveiled via copper-catalyzed nitrile formation, hydrolysis, and reduction in one pot for the first time. In this reaction, urea is used as a source of nitrogen for nitrile formation, hydrazine hydrate is used for both the reduction of the nitro group and the hydrolysis of nitrile, and atmospheric oxygen is used as the sole oxidant. The method portrays a wide substrate scope with good functional group tolerances. Moreover, this method was applied for the synthesis of schizocommunin, tryptanthrin, phaitanthrin-A, phaitanthrin-B, and 8H-quinazolino[4,3-b]-quinazolin-8-one.
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