期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 99, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2021.108843
关键词
Apoptosis; EGCG; KRas mutation; Notch signaling pathway; Tongue squamous cell carcinoma
资金
- National Natural Sciences Foundation of China [81572286, 81641105]
- Joint Funds for the Innovation of Science and Technology, Fujian Province [2017Y9096]
- Natural Sciences Foundation of Fujian Province [2020J01648]
- Scientific research funding of School and Hospital of Stomatology, Fujian Medical University [2018KQYJ01]
EGCG, as an effective chemotherapeutic agent for tongue cancer, targets the Notch pathway to induce cell apoptosis and inhibit cell proliferation, thereby prolonging the lifespan of mice.
Epigallocatechin-3-gallate (EGCG), the main active ingredient of green tea, exhibits low toxic side effect and versatile bioactivities, and its anti-cancer effect has been extensively studied. Most of the studies used cancer cell lines and xenograft models. However, whether EGCG can prevent tumor onset after cancer-associated mutations occur is still controversial. In the present study, Krt14-cre/ERT-Kras transgenic mice were developed and the expression of K-RasG12D was induced by tamoxifen. Two weeks after induction, the K-Ras mutant mice developed exophytic tumoral lesions on the lips and tongues, with significant activation of Notch signaling pathway. Administration of EGCG effectively delayed the time of appearance, decreased the size and weight of tumoral lesions, relieved heterotypic hyperplasia of tumoral lesions, and prolonged the life of the mice. The Notch signaling pathway was significantly inhibited by EGCG in the tumoral lesions. Furthermore, EGCG significantly induced cell apoptosis and inhibited the proliferation of tongue cancer cells by blocking the activation of Notch signaling pathway. Taken together, these results indicate EGCG as an effective chemotherapeutic agent for tongue cancer by targeting Notch pathway. (c) 2021 Elsevier Inc. All rights reserved.
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