How shall we judge a PET flow model?

Article Cardiac & Cardiovascular Systems

Mortality Prediction by Quantitative PET Perfusion Expressed as Coronary Flow Capacity With and Without Revascularization

K. Lance Gould et al.

Summary: This study aimed to explore the relationship between reduced quantitative perfusion parameters and mortality with and without revascularization. It found that severely reduced CFR and stress perfusion incurred increasing size-dependent risks, with severely reduced CFC associated with the highest major adverse cardiac event rate and mortality risk. Small regions of CFCsevere predicted high risk due to border zones at risk around the severe center, and this risk could be reduced by revascularization.

JACC-CARDIOVASCULAR IMAGING (2021)

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Article Cardiac & Cardiovascular Systems

Design and rationale of the randomized trial of comprehensive lifestyle modification, optimal pharmacological treatment and utilizing PET imaging for quantifying and managing stable coronar y ar ter y disease (the CENTURY study)

Danai Kitkungvan et al.

Summary: The CENTURY Study is the first randomized-controlled trial in stable CAD patients aiming to test the incremental benefit of a comprehensive management strategy incorporating intense lifestyle modification, medical treatment to specific goals, and high-precision quantitative cardiac PET imaging to guide interventions. The study has randomized 1028 patients, and the 5-year follow-up will be completed in 2022.

AMERICAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Normal values of thermodilution-derived absolute coronary blood flow and microvascular resistance in humans

Stephane Fournier et al.

Summary: This study aimed to assess normal reference values of coronary hyperemic blood flow and resistance, finding that hyperemic flow was significantly higher in controls compared to patients in different coronary arteries. However, when considering vessel-specific myocardial mass, hyperemic flow was similar in the three vascular territories.

EUROINTERVENTION (2021)

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Letter Cardiac & Cardiovascular Systems