期刊
JOURNAL OF NEUROTRAUMA
卷 38, 期 23, 页码 3186-3194出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2021.0216
关键词
adult brain injury; head trauma; traumatic brain injury
资金
- NINDS
- Alzheimer's Association
- GHR Foundation
- Biogen
- Alzheimer's Drug Discovery Foundation
- American Stroke Association, a division of the American Heart Association
- CurePSP
- John A. Hartford Foundation
- WellMed Charitable Foundation
- NIA
- EIP Pharma
- Accelerate Cure/Treatments for Alzheimer's Disease (ACT-AD) Coalition
- NIH Office of Disease Prevention
- Foundation for the National Institutes of Health
Traumatic brain injury (TBI) is a risk factor for later-life dementia, as highlighted in the 2019 ADRD Summit which emphasized the importance of enhancing communication and building research frameworks between TBI and dementia researchers.
Traumatic brain injury (TBI) is a risk factor for later-life dementia. Clinical and pre-clinical studies have elucidated multiple mechanisms through which TBI may influence or exacerbate multiple pathological processes underlying Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). The National Institutes of Health hosts triennial ADRD Summits to inform a national research agenda, and the 2019 ADRD Summit was the first to highlight TBI and AD/ADRD Risk as an emerging topic in the field. A multidisciplinary committee of TBI researchers with relevant expertise reviewed extant literature, identified research gaps and opportunities, and proposed draft research recommendations at the 2019 ADRD Summit. These research recommendations, further refined after broad stakeholder input at the Summit, cover four overall areas: 1) Encourage crosstalk and interdisciplinary collaboration between TBI and dementia researchers; 2) Establish infrastructure to study TBI as a risk factor for AD/ADRD; 3) Promote basic and clinical research examining the development and progression of TBI AD/ADRD neuropathologies and associated clinical symptoms; and 4) Characterize the clinical phenotype of progressive dementia associated with TBI and develop non-invasive diagnostic approaches. These recommendations recognize a need to strengthen communication and build frameworks to connect the complexity of TBI with rapidly evolving AD/ADRD research. Recommendations acknowledge TBI as a clinically and pathologically heterogeneous disease whose associations with AD/ADRDs remain incompletely understood. The recommendations highlight the scientific advantage of investigating AD/ADRD in the context of a known TBI exposure, the study of which can directly inform on disease mechanisms and treatment targets for AD/ADRDs with shared common pathways.
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