期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 100, 期 3, 页码 855-868出版社
WILEY
DOI: 10.1002/jnr.25007
关键词
experimental autoimmune encephalomyelitis; myelin oligodendrocyte glycoprotein; optic neuritis; RRID; AB_1158338; RRID; AB_2566782; RRID; AB_305055; RRID; AB_839504; RRID; SCR_019096; visual evoked potentials
资金
- Regione Lombardia
- Ministero dell'Istruzione, dell'Universita e della Ricerca [CTN01_00177_165430]
- Merck KGaA
In this study, female Dark Agouti rats were immunized with increasing doses of myelin oligodendrocyte glycoprotein (MOG) to develop experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis. The results showed that increasing MOG dosage augmented visual function impairment in EAE, which could be monitored with noninvasive visual evoked potentials (VEPs) to assess demyelination and axonal loss along optic nerves (ONs).
Female Dark Agouti rats were immunized with increasing doses of myelin oligodendrocyte glycoprotein (MOG) to develop experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis. Typical EAE motor impairments were assessed daily and noninvasive visual evoked potentials (VEPs) were recorded at baseline and 5 weeks after immunization, with final histopathology of optic nerves (ONs). Immunized rats exhibited a relapsing-remitting clinical course. Both VEP and histological abnormalities were detected in a MOG dose-dependent gradient. Increasing MOG dosage augmented visual function impairment in EAE, which could be monitored with VEP recording to assess demyelination and axonal loss along ONs.
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