期刊
JOURNAL OF NEUROSCIENCE
卷 42, 期 1, 页码 109-120出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0958-21.2021
关键词
anorexia nervosa; cognitive neuroscience; decision-making; fMRI; machine learning; orbitofrontal cortex
资金
- Global Foundation for Eating Disorders
- National Institute for Mental Health [R01 MH079397, K23 MH076195, K24 MH113737]
- National Science Foundation [1606916]
- McKnight Foundation
- Klarman Family Foundation
- SBE Off Of Multidisciplinary Activities
- Direct For Social, Behav & Economic Scie [1606916] Funding Source: National Science Foundation
Decisions about what to eat involve the OFC and the evaluation of taste and health attributes. By using fMRI and behavioral tasks, this study found that activity patterns in the OFC can decode subjective ratings of tastiness and healthiness. However, the OFC activity related to health attributes is more related to choice preferences in patients with AN compared to healthy individuals.
Decisions about what to eat recruit the orbitofrontal cortex (OFC) and involve the evaluation of food-related attributes such as taste and health. These attributes are used differently by healthy individuals and patients with disordered eating behavior, but it is unclear whether these attributes are decodable from activity in the OFC in both groups and whether neural representations of these attributes are differentially related to decisions about food. We used fMRI combined with behavioral tasks to investigate the representation of taste and health attributes in the human OFC and the role of these representations in food choices in healthy women and women with anorexia nervosa (AN). We found that subjective ratings of tastiness and healthiness could be decoded from patterns of activity in the OFC in both groups. However, health-related patterns of activity in the OFC were more related to the magnitude of choice preferences among patients with AN than healthy individuals. These findings suggest that maladaptive decision-making in AN is associated with more consideration of health information represented by the OFC during deliberation about what to eat.
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