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Poul Jørgensen et al.
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Novel role of presenilins in maturation and transport of integrin β1
Kun Zou et al.
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Kun Zou et al.
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Bart De Strooper
EMBO REPORTS (2007)
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Prim de Bie et al.
BIOCHEMICAL JOURNAL (2006)
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N Watanabe et al.
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TA Comery et al.
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YW Zhang et al.
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γ-secretase complex assembly within the early secretory pathway
A Capell et al.
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K Del Villar et al.
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DS Goldfarb et al.
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A Bergman et al.
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Positive and negative regulation of the γ-secretase activity by nicastrin in a murine model
JH Li et al.
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WT Kimberly et al.
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N Takasugi et al.
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JS Gong et al.
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DM Holtzman et al.
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M Michikawa et al.
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