期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 127, 期 2, 页码 393-396出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00525.2021
关键词
afterdischarge; brain network; epileptogenesis; optogenetics; seizure onset zone
This article utilizes new tools to study the dynamics of the whole brain during epileptic seizures originating in the hippocampus, revealing how various brain regions are recruited to seizures and uncovering a novel form of migrating seizure core.
Epilepsy is often labeled as a network disorder, though a common view of seizures holds that they initiate in a singular onset zone before expanding contiguously outward. A recent report by Choy et al. (Choy M, Dadgar-Kiani E, Cron GO, Duffy BA, Schmid F, Edelman BJ, Asaad M, Chan RW, Vandat S, Lee JH. Neuron 2021 Oct 23: S0896-6273(21)00778-9.) leverages new tools to study whole brain dynamics during epileptic seizures originating in the hippocampus. Cell-type-specific kindling and functional imaging revealed how various brain regions were recruited to seizures and uncovered a novel form of migrating seizure core.
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