期刊
ILAR JOURNAL
卷 56, 期 3, 页码 283-296出版社
OXFORD UNIV PRESS
DOI: 10.1093/ilar/ilv041
关键词
calves; elephant endotheliotropic herpesvirus (EEHV); elephant hemorrhagic disease; Elephas maximus; Loxodonta Africana; lung and skin nodules; Probosciviruses
资金
- NIAID, National Institutes of Health
- DHEW
- International Elephant Foundation
- IMLS National Leadership Collections Stewardship Program
- Morris Animal Foundation Postdoctoral Fellowship [D14ZO-411]
- Smithsonian Institution
- National Zoo
- Morris Animal Foundation
- Ringling Bros & Barnum and Bailey Center for Elephant Conservation
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI024576] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008752] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [T32OD011089] Funding Source: NIH RePORTER
More than 100 young captive and wild Asian elephants are known to have died from a rapid-onset, acute hemorrhagic disease caused primarily by multiple distinct strains of two closely related chimeric variants of a novel herpesvirus species designated elephant endotheliotropic herpesvirus (EEHV1A and EEHV1B). These and two other species ofProbosciviruses (EEHV4 and EEHV5) are evidently ancient and likely nearly ubiquitous asymptomatic infections of adult Asian elephants worldwide that are occasionally shed in trunk wash secretions. Although only a handful of similar cases have been observed in African elephants, they also have proved to harbor their own multiple and distinct species of Probosciviruses-EEHV2, EEHV3, EEHV6, and EEHV7-found in lung and skin nodules or saliva. For reasons that are not yet understood, approximately 20% of Asian elephant calves appear to be susceptible to the disease when primary infections are not controlled by normal innate cellular and humoral immune responses. Sensitive specific polymerase chain reaction (PCR) DNA blood tests have been developed, routine monitoring has been established, the complete large DNA genomes of each of the four Asian EEHV species have now been sequenced, and PCR gene subtyping has provided unambiguous evidence that this is a sporadic rather than epidemic disease that it is not being spread among zoos or other elephant housing facilities. Nevertheless, researchers have not yet been able to propagate EEHV in cell culture, determine whether or not human antiherpesvirus drugs are effective inhibitors, or develop serology assays that can distinguish between antibodies against the multiple different EEHV species.
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