期刊
JOURNAL OF NEUROLOGY
卷 269, 期 6, 页码 3129-3135出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-021-10901-2
关键词
Multiple sclerosis; Spinal cord; Magnetic resonance imaging; NEDA; No evidence of disease activity; Disease activity; Monitoring
The impact of spinal cord MRI on the definition of NEDA in patients with MS was significant, leading to a slight but significant change in the proportion of subjects classified as clinically and radiologically stable.
Background Measures to define treatment response, such as no evidence of disease activity (NEDA), are routinely used in multiple sclerosis (MS) clinical practice. Although spinal cord involvement is a frequent feature of MS, its magnetic resonance imaging (MRI) monitoring is not routinely performed. Objective To assess the impact of spinal cord MRI in the definition of NEDA in a cohort of people with MS (pwMS) with available spinal cord imaging performed as for routine monitoring. Methods We included 115 pwMS undergoing treatment with first-line disease-modifying therapies (DMTs) and retrospectively analyzed the presence of NEDA in the whole cohort, either considering or not spinal cord imaging. Results When considering only clinical and brain MRI measures, 97 out of 115 pwMS (84.3%) satisfied the criteria for NEDA. In the same cohort, the number of pwMS with NEDA significantly decreased to 88 (76.5%) (p < 0.01) when considering also spinal cord imaging. Conclusion These findings suggest that, in routine clinical practice, spinal cord MRI monitoring in pwMS under first-line DMTs leads to a slight but significant change in the proportion of subjects classified as clinically and radiologically stable according to the NEDA definition.
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