期刊
JOURNAL OF NEUROLOGY
卷 269, 期 6, 页码 2892-2909出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-022-10963-w
关键词
Dopamine; L-DOPA; Diet; Parkinson's disease
资金
- NINDS [5R01NS071122-10]
- OD [1S10OD020026-01]
- NIDA [5R01DA026947-11]
This manuscript provides a comprehensive review of treatment protocols, absorption, distribution, and drug/food interactions related to L-DOPA-induced dyskinesia, and discusses current strategies and future directions.
Over the past two decades, animal models of Parkinson's disease (PD) have helped to determine the plausible underlying mechanism of levo-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia following L-DOPA treatment. However, our understanding of the mechanisms related to this phenomenon remains incomplete. The purpose of this manuscript is to provide a comprehensive review of treatment protocols used for assessing the occurrence of L-DOPA-induced dyskinesia, L-DOPA absorption, distribution, drug/food interaction, and discuss current strategies and future directions. This review offers a historical perspective using L-DOPA in animal models of PD and the occurrence of L-DOPA-induced dyskinesia.
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