4.7 Article

Reclassification of patients with tremor syndrome and comparisons of essential tremor and essential tremor-plus patients

期刊

JOURNAL OF NEUROLOGY
卷 269, 期 7, 页码 3653-3662

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s00415-022-10985-4

关键词

Classification; Essential tremor; Essential tremor plus; Motor symptoms; Non-motor symptoms

资金

  1. National Natural Science Foundation of China [81801272]
  2. Sichuan Science and Technology Program [2018FZ0029, 2018HH0077]
  3. Fundamental Research Funds for the Central Universities [2018SCU12029]

向作者/读者索取更多资源

This study reclassified and compared the characteristics of ET and ET-plus patients in a large Chinese tremor cohort. The results showed that ET-plus patients were older, had longer disease durations, worse tremor manifestations, and more distinct non-motor symptoms. Certain additional soft signs of ET-plus were associated with tremor severity or worse quality of life.
Background The new essential tremor (ET)-plus nomenclature was proposed by the 2018 Tremor Consensus Criteria. However, few studies have adopted this usage and the clinical differences between ET and ET-plus remains unclear. To address this issue, we reclassified and compared the characteristics of ET and ET-plus patients in a large Chinese tremor cohort. Methods In this cross-sectional observational study, 766 patients originally diagnosed with ET underwent neurological examination. Scale ratings were used to evaluate motor and non-motor symptoms, and quality of life (QoL). We then reclassified the ET cohort and compared demographic and clinical characteristics between ET and ET-plus patients. A logistic regression analysis was used to explore whether the presence of neurological soft signs in ET-plus was associated with tremor severity or QoL. Results Among 665 clinically confirmed ET syndrome patients, 274 were ET and 391 were ET-plus. The most prevalent neurological soft sign was resting tremor. ET-plus patients were older, had older age at onset and longer disease duration. ET-plus patients recorded higher scores in tremor severity evaluations and lower in cognitive evaluations, whereas a higher proportion of patients presented with depression or anxiety symptoms. Resting tremor and questionable cerebellar signs were associated with tremor severity. Cognitive impairment was associated with worse QoL. Conclusions ET-plus patients were older, had longer disease durations, worse tremor manifestations, and more distinct non-motor symptoms. Certain additional soft signs of ET-plus were associated with tremor severity or worse QoL. ET-plus patients may include advanced ET patients with additional neurological soft signs presenting along with disease progression.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据