4.7 Article

Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Non-canonical glutamate signaling in a genetic model of migraine with aura

Patrick D. Parker et al.

Summary: A study on mice with familial hemiplegic migraine type 2 (FHM2) mutation found slower clearance during sensory processing and spontaneous plumes of glutamate. These plumes, predicted by elevated basal glutamate levels and plume frequency, provide a novel mechanism for migraine with aura onset.

NEURON (2021)

Article Clinical Neurology

Increased branched-chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain

Caroline Ong et al.

Summary: This study monitored extracellular brain chemistry dynamics in patients with refractory epilepsy and found that branched-chain amino acids (BCAAs) and glutamate were chronically elevated in brain regions of seizure onset and propagation. Interestingly, isoleucine increased significantly above baseline as early as 3 hours before a spontaneous seizure, suggesting a potential role of BCAAs in the pathogenesis of spontaneous seizures.

EPILEPSIA (2021)

Review Endocrinology & Metabolism

Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS

Syuichi Tetsuka et al.

Summary: MELAS should be considered in the differential diagnosis of acute ischemic stroke due to similar onset patterns and neurological symptoms. Advances in neuroimaging have facilitated differentiation between stroke and MELAS. Potential preventive treatments for stroke-like episodes in MELAS include supplementation with L-arginine or taurine, while new gene therapies offer promise for future treatment options.

METABOLIC BRAIN DISEASE (2021)

Review Clinical Neurology

Systematic review of cognitive deficits in adult mitochondrial disease

H. L. Moore et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

Article Biochemistry & Molecular Biology

Glutamate Transporters and Mitochondria: Signaling, Co-compartmentalization, Functional Coupling, and Future Directions

Michael B. Robinson et al.

NEUROCHEMICAL RESEARCH (2020)

Review Clinical Neurology

Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications

Jordi Olloquequi et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2018)

Review Neurosciences

Lactate in the brain: from metabolic end-product to signalling molecule

Pierre J. Magistretti et al.

NATURE REVIEWS NEUROSCIENCE (2018)

Article Nutrition & Dietetics

Are patients affected by mitochondrial disorders at nutritional risk?

Emilie Aubry et al.

NUTRITION (2018)

Review Nutrition & Dietetics

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

Vinicius Cruzat et al.

NUTRIENTS (2018)

Article Biochemistry & Molecular Biology

Interactions in the Metabolism of Glutamate and the Branched-Chain Amino Acids and Ketoacids in the CNS

Marc Yudkoff

NEUROCHEMICAL RESEARCH (2017)

Article Clinical Neurology

Cortical glutamate in migraine

Ronald Zielman et al.

Article Clinical Neurology

Prevalence of migraine in persons with the 3243A>G mutation in mitochondrial DNA

S. Guo et al.

EUROPEAN JOURNAL OF NEUROLOGY (2016)

Article Biochemistry & Molecular Biology

The importance of the excitatory amino acid transporter 3 (EAAT3)

Walden E. Bjorn-Yoshimoto et al.

NEUROCHEMISTRY INTERNATIONAL (2016)

Review Endocrinology & Metabolism

MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options

Ayman W. El-Hattab et al.

MOLECULAR GENETICS AND METABOLISM (2015)

Article Endocrinology & Metabolism

Characterization of cerebral glutamine uptake from blood in the mouse brain: implications for metabolic modeling of 13C NMR data

Puneet Bagga et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)

Article Biochemistry & Molecular Biology

MELAS: A nationwide prospective cohort study of 96 patients in Japan

Shuichi Yatsuga et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

Article Biochemistry & Molecular Biology

Is there In Vivo Evidence for Amino Acid Shuttles Carrying Ammonia from Neurons to Astrocytes?

Douglas L. Rothman et al.

NEUROCHEMICAL RESEARCH (2012)

Review Biochemistry & Molecular Biology

Astroglia in dementia and Alzheimer's disease

J. J. Rodriguez et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Neurosciences

MELAS mitochondrial DNA mutation A3243G reduces glutamate transport in cybrids cell lines

Jacopo C. DiFrancesco et al.

EXPERIMENTAL NEUROLOGY (2008)

Review Endocrinology & Metabolism

Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis

Leif Hertz et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)

Article Nutrition & Dietetics

Structure of the blood-brain barrier and its role in the transport of amino acids

RA Hawkins et al.

JOURNAL OF NUTRITION (2006)

Review Clinical Neurology

Pathogenesis of stroke-like episodes in MELAS: Analysis of neurovascular cellular mechanisms

T Iizuka et al.

CURRENT NEUROVASCULAR RESEARCH (2005)

Review Biochemistry & Molecular Biology

Taurine and neural cell damage

P Saransaari et al.

AMINO ACIDS (2000)