期刊
JOURNAL OF NEUROINTERVENTIONAL SURGERY
卷 14, 期 6, 页码 533-538出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/neurintsurg-2021-018190
关键词
angiography; brain; intervention; neoplasm; tumor
资金
- National Cancer Institute [1R01CA214749, 1R01CA247970, P30CA016672, 2P50CA127001]
- University of Texas MD Anderson Moon Shots Program TM
- Broach Foundation for Brain Cancer Research
- Elias Family Fund
- Priscila and Jason Hiley Fund
- Baumann Family/Curefest Fund
- Jim and Pam Harris Fund
- Gene Pennebaker Brain Cancer Fund
- Schneider Memorial Cancer Research Fund
- Sweet Family Cancer Research Fund
- Dr Marnie Rose Foundation
- Gold Family Memorial Fund
- Sorenson Foundation
This study for the first time utilizes perfusion guidance to enhance the precision of glioblastoma treatment, improving targeted delivery of therapeutic agents through MRI imaging and volumetric perfusion imaging.
Background Survival for glioblastoma remains very poor despite decades of research, with a 5-year survival of only 5%. The technological improvements that have revolutionized treatment of ischemic stroke and brain aneurysms have great potential in providing more precise and selective delivery of cancer therapeutic agents to brain tumors. Methods We describe for the first time the use of perfusion guidance to enhance the precision of endovascular super-selective intra-arterial (ESIA) infusions of mesenchymal stem cells loaded with Delta-24 (MSC-D24) in the treatment of glioblastoma (NCT 03896568). Results MRI imaging, which best defines the location of the tumor, is co-registered and fused with the patient's position using cone beam CT, resulting in optimal vessel selection and confirmation of targeted delivery through volumetric perfusion imaging. Conclusions This technique of perfusion guided-ESIA injections (PG-ESIA) enhances our ability to perform targeted super-selective delivery of therapeutic agents for brain tumors.
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