期刊
JOURNAL OF NEUROINFLAMMATION
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12974-021-02309-6
关键词
Microglia; Inflammation; Homeostasis; Stress; Parainflammation; Depression
资金
- National Institutes of Health [F32-MH123051, R21-MH120614, R01-MH-123545]
Microglia are increasingly recognized as critical regulators of neuronal function and behavior in neuroscience. Research has shifted focus from their classical immune functions in pathological contexts to neuro-immune interactions in the absence of disease, injury, or infection. Standard methods to study and define microglial phenotype and function are being developed to facilitate the development of microglia-directed therapeutics in psychiatric and neurological diseases.
Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area of neuroscience. Initial reports focused on classical immune functions of microglia in pathological contexts, however, immunological concepts from these studies have been applied to describe neuro-immune interactions in the absence of disease, injury, or infection. Indeed, terms such as 'microglia activation' or 'neuroinflammation' are used ubiquitously to describe changes in neuro-immune function in disparate contexts; particularly in stress research, where these terms prompt undue comparisons to pathological conditions. This creates a barrier for investigators new to neuro-immunology and ultimately hinders our understanding of stress effects on microglia. As more studies seek to understand the role of microglia in neurobiology and behavior, it is increasingly important to develop standard methods to study and define microglial phenotype and function. In this review, we summarize primary research on the role of microglia in pathological and physiological contexts. Further, we propose a framework to better describe changes in microglia1 phenotype and function in chronic stress. This approach will enable more precise characterization of microglia in different contexts, which should facilitate development of microglia-directed therapeutics in psychiatric and neurological disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据