4.7 Article

Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Agonist that activates the mu-opioid receptor in acidified microenvironments inhibits colitis pain without side effects

Nestor Nivardo Jimenez-Vargas et al.

Summary: The fentanyl analogue NFEPP demonstrated effectiveness in inhibiting pain response in mice with colitis in an acidic environment, without causing respiratory depression, constipation, or hyperactivity. In contrast, fentanyl inhibited pain responses in both groups of mice and had side effects such as respiratory depression and hyperactivity.
Review Gastroenterology & Hepatology

Opioid Use Among Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Blake Niccum et al.

Summary: In a systematic review and meta-analysis, it was found that 21% of outpatients with IBD (and 62% of hospitalized patients) are opioid users. Opioid use is associated with more severe IBD and increased healthcare use, suggesting urgent interventions are needed to reduce opioid use and improve disease-related outcomes.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis

Julien Pujo et al.

Summary: In this study, it was found that a probiotic strain contained increased levels of 3-hydroxyoctadecaenoic acid (C18-3OH), which was shown to decrease colitis in mice and was associated with anti-inflammatory properties of prebiotic fructooligosaccharides (FOS). The concentration of C18-3OH was correlated with an increase in specific bacterial genera in the microbiota. This suggests that C18-3OH production by bacteria could play a role in the anti-inflammatory properties of probiotics and in microbiota/host interactions.
Review Biochemistry & Molecular Biology

T Cells as Guardians of Pain Resolution

Annemieke Kavelaars et al.

Summary: Research indicates that T cells play a critical role in pain suppression, with the immune system actively involved in pain resolution. This suggests that immunosuppressive drugs may not be sufficient to control pain, and dysregulation of immune functions may promote the transition to chronic pain. Stimulating endogenous immune-mediated resolution pathways could be a potent approach to treating chronic pain.

TRENDS IN MOLECULAR MEDICINE (2021)

Article Clinical Neurology

Pain Management in a Model of Interstitial Cystitis/Bladder Pain Syndrome by a Vaccinal Strategy

Celine Auge et al.

Summary: The study suggests a novel analgesic strategy utilizing the opioid-mediated analgesic properties of T lymphocytes to alleviate bladder pain in IC/BPS patients. In a rat model, a secondary T cell response against intravesically administered antigens was found to prevent visceral pain, indicating potential for pain management in IC/BPS patients.

FRONTIERS IN PAIN RESEARCH (2021)

Article Gastroenterology & Hepatology

Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice

Lilian Basso et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

Review Gastroenterology & Hepatology

Inflammation without pain: Immune-derived opioids hold the key

Simona E. Carbone et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

Article Multidisciplinary Sciences

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

Nestor N. Jimenez-Vargas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors

Ana Baamonde et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine

Jiao Feng et al.

SCIENCE ADVANCES (2019)

Article Gastroenterology & Hepatology

T-lymphocyte-derived enkephalins reduce T(h)1/T(h)17 colitis and associated pain in mice

Lilian Basso et al.

JOURNAL OF GASTROENTEROLOGY (2018)

Article Pharmacology & Pharmacy

Co-expression of μ and δ opioid receptors by mouse colonic nociceptors

Raquel Guerrero-Alba et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

New concepts in opioid analgesia

Christoph Stein

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2018)

Review Pharmacology & Pharmacy

Advances in Achieving Opioid Analgesia Without Side Effects

Halina Machelska et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Anesthesiology

Mu and delta opioid receptor knockout mice show increased colonic sensitivity

D. Reiss et al.

EUROPEAN JOURNAL OF PAIN (2017)

Article Immunology

Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis

Uta Baddack-Werncke et al.

JOURNAL OF NEUROINFLAMMATION (2017)

Article Biochemistry & Molecular Biology

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics

Cullen L. Schmid et al.

Review Anesthesiology

The US Opioid Crisis: Current Federal and State Legal Issues

Cobin D. Soelberg et al.

ANESTHESIA AND ANALGESIA (2017)

Review Gastroenterology & Hepatology

Opioidergic effects on enteric and sensory nerves in the lower GI tract: basic mechanisms and clinical implications

Patrick A. Hughes et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Article Immunology

Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice

Lilian Basso et al.

JOURNAL OF NEUROINFLAMMATION (2016)

Article Multidisciplinary Sciences

Structure-based discovery of opioid analgesics with reduced side effects

Aashish Manglik et al.

NATURE (2016)

Review Pharmacology & Pharmacy

Molecular Pharmacology of δ-Opioid Receptors

Louis Gendron et al.

PHARMACOLOGICAL REVIEWS (2016)

Article Pharmacology & Pharmacy

Intestinal inflammation and pain management

Lilian Basso et al.

CURRENT OPINION IN PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications

N. T. Burford et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Article Gastroenterology & Hepatology

The Prevalence and Predictors of Opioid Use in Inflammatory Bowel Disease: A Population-Based Analysis

Laura E. Targownik et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

Endogenous Regulation of Visceral Pain via Production of Opioids by Colitogenic CD4+ T Cells in Mice

Jerome Boue et al.

GASTROENTEROLOGY (2014)

Review Gastroenterology & Hepatology

Endogenous Regulation of Inflammatory Pain by T-cell-derived Opioids: When Friend Turns to Foe

Lilian Basso et al.

INFLAMMATORY BOWEL DISEASES (2014)

Article Gastroenterology & Hepatology

Release of endogenous opioids during a chronic IBD model suppresses the excitability of colonic DRG neurons

E. Valdez-Morales et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2013)

Article Multidisciplinary Sciences

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

Susruta Majumdar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Gastroenterology & Hepatology

CD4+ T-cell modulation of visceral nociception in mice

Monica Verma-Gandhu et al.

GASTROENTEROLOGY (2006)

Article Multidisciplinary Sciences

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

MA Nassar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Pharmacology & Pharmacy

The expression of β- and κ-opioid receptor is enhanced during intestinal inflammation in mice

O Pol et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)

Article Medicine, Research & Experimental

Anti-inflammatory properties of the μ opioid receptor support its use in the treatment of colon inflammation

D Philippe et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Pharmacology & Pharmacy

Inflammation enhances μ-opioid receptor transcription and expression in mice intestine

O Pol et al.

MOLECULAR PHARMACOLOGY (2001)