期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 362, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2021.577786
关键词
Hemorrhagic stroke; Nurr1 ligand; Amodiaquine; Neuroprotection; Microglia
资金
- The Smoking Research Foundation
- Koyanagi Foundation
- JSPS KAKENHI, MEXT, Japan [16H04673, 19K22813, 20H04126]
Hydroxychloroquine can exhibit neuroprotective effects in a mouse model of intracerebral hemorrhage, primarily by preserving neurons and preventing axon structure fragmentation.
We examined the effect of an immunomodulator hydroxychloroquine, also known as a Nurr1 ligand and an autophagy inhibitor, on a mouse model of intracerebral hemorrhage (ICH). Daily administration of hydroxychloroquine (100 mg/kg, i.p.) from 3 h after induction of ICH alleviated neurological deficits of mice, increased the number of surviving neurons in the hematoma and prevented fragmentation of axon structures in the internal capsule. Unexpectedly, hydroxychloroquine did not inhibit either upregulation of pro-inflammatory mediators or autophagic responses in the brain. Hence, hydroxychloroquine may produce therapeutic effects on ICH primarily via neuroprotection including preservation of the axon tract integrity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据