4.5 Article

Lipidome changes in alcohol-related brain damage

期刊

JOURNAL OF NEUROCHEMISTRY
卷 160, 期 2, 页码 271-282

出版社

WILEY
DOI: 10.1111/jnc.15530

关键词

alcohol use disorder; alcohol-related brain injury; LCMS; lipidomics; post-mortem brain

资金

  1. National Institute of Alcohol Abuse and Alcoholism [R28AA012725]

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Chronic alcohol abuse results in selective changes to the neurolipidome, predominantly in the prefrontal and visual cortices, including broad decreases to phospholipids and ceramide, decreased polyunsaturated fatty acids, and selective decreases in cholesteryl ester fatty acid chains. These changes likely reflect both the direct effects on the brain and concurrent effects on the liver.
Alcohol-related brain injury is characterized by cognitive deficits and brain atrophy with the prefrontal cortex particularly susceptible. White matter in the human brain is lipid rich and a major target of damage from chronic alcohol abuse; yet, there is sparse information on how these lipids are affected. Here, we used untargeted lipidomics as a discovery tool to describe these changes in the prefrontal, middle temporal, and visual cortices of human subjects with alcohol use disorder and controls. Significant changes to the lipidome, predominantly in the prefrontal and visual cortices, and differences between the white and grey matter of each brain region were identified. These effects include broad decreases to phospholipids and ceramide, decreased polyunsaturated fatty acids, decreased sphingadiene backbones, and selective decreases in cholesteryl ester fatty acid chains. Our findings show that chronic alcohol abuse results in selective changes to the neurolipidome, which likely reflects both the directs effects on the brain and concurrent effects on the liver.

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