期刊
JOURNAL OF NEUROCHEMISTRY
卷 162, 期 1, 页码 109-127出版社
WILEY
DOI: 10.1111/jnc.15544
关键词
Alzheimer's disease; ayahuasca; BPSD; frontotemporal dementia; neurodegeneration; neuroplasticity; psilocybin; psychedelic; psychoplastogen
资金
- Camille and Henry Dreyfus Foundation
- Dr. Mohsen Najafi Research Award in Medicinal Chemistry
- National Institutes of Health [5T32MH112507, P30AG010129, R01GM128997]
Psychedelics are increasingly recognized for their potential to treat various brain disorders by influencing gene expression, activating neuronal mechanisms, and modulating the immune system. While not yet extended to neurodegenerative disorders, approaches based on psychedelic science may be useful for treating these diseases. The primary target of psychedelics, the 5-HT2A receptor, plays important roles in neuronal health and may have implications for diseases like Alzheimer's and dementia.
Psychedelics are increasingly being recognized for their potential to treat a wide range of brain disorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder. Their broad therapeutic potential might result from an ability to rescue cortical atrophy common to many neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor gene expression, activating neuronal growth and survival mechanisms, and modulating the immune system. While the therapeutic potential of psychedelics has not yet been extended to neurodegenerative disorders, we provide evidence suggesting that approaches based on psychedelic science might prove useful for treating these diseases. The primary target of psychedelics, the 5-HT2A receptor, plays key roles in cortical neuron health and is dysregulated in Alzheimer's disease. Moreover, evidence suggests that psychedelics and related compounds could prove useful for treating the behavioral and psychological symptoms of dementia (BPSD). While more research is needed to probe the effects of psychedelics in models of neurodegenerative diseases, the robust effects of these compounds on structural and functional neuroplasticity and inflammation clearly warrant further investigation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据