期刊
JOURNAL OF NATURAL PRODUCTS
卷 85, 期 3, 页码 501-510出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.1c01102
关键词
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资金
- National Research Foundation of Korea [NRF-2019R1A4A1020626, NRF-2021R1A2C1004958]
New hybrid compounds and polyketides with potential therapeutic effects on metabolic diseases were isolated from ahalophyte-associated fungus. One of the compounds displayed a similar biological activity to aspirin.
Three new cyclic peptide-polyketide hybrids (1-3) and two new chaetiacandin-type polyketides (4and5) along with nine known compounds were isolated from cultures of ahalophyte-associated fungus,Colletotrichum gloeosporioidesJS0417.Spectroscopic analysis revealed that1-3were cyclic depsipeptideswhere 3,5,11-trihydroxy-2,6-dimethyldodecanoic acid was linked totwo amino acids through amide and ester bonds to form a 12-membered ring. Relative and absolute configurations for thepeptides were determined with spectroscopic analysis and chemicalreactions. The cyclic depsipeptides2and6were determined to actas strong adiponectin-secretion-promoting modulators withpotential to treat metabolic diseases associated with hypoadiponectinemia. Notably, a known compound, tryptophol, significantlyinhibited PGE2synthesis and also promoted adiponectin secretion, exhibiting a similar biological activity profile to aspirin, but withgreater potency. The presence of an isoleucine moiety and non-glycosylation may be important for biological activity of the cyclicpeptide-polyketide hybrids, and non-methoxylation of the side chain may influence activity of the indole derivatives
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