期刊
JOURNAL OF NATURAL PRODUCTS
卷 84, 期 12, 页码 3110-3116出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.1c00881
关键词
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资金
- National Natural Science Foundation of China [81703504]
- Shandong Key Research and Development Program [2019GSF107092]
- China Postdoctoral Science Foundation [2019M662294]
The natural alkaloid evodiamine was found to lower blood lipids and reduce hepatic lipid accumulation in HFD-fed mice, likely through promoting the PPARγ-ABCG1 signaling pathway.
The natural alkaloid evodiamine enhances cholesterol efflux from cultured THP-1-derived macrophages, but whether it has any impact on blood lipids in vivo remains unknown. In this study, the effect of evodiamine on hyperlipidemia induced by a high-fat diet (HFD) was investigated in mice. Intragastric administrations of evodiamine (10 and 20 mg/kg) for 8 weeks resulted in a significant improvement of metabolic lipid profiles by reducing the plasma levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C). Evodiamine also significantly decreased hepatic lipid accumulation and hepatic total bile acids (TBA). Mechanistically, evodiamine increased ATP-binding cassette transporter G1 (ABCG1) mRNA and protein expression and up-regulated peroxisome proliferator-activated receptor gamma (PPAR gamma) expression in the liver. Taken together, the natural product evodiamine lowers blood lipids in HFD-fed mice likely through promoting the PPAR gamma-ABCG1 signaling pathway.
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