Thannilignan glucoside and 2-(beta-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from Terminalia bellirica

Two new compounds, thannilignan 9-O-beta-glucoside (1) and 2-(beta-glucopyranosyl)-3-isoxazolin-5-one derivative (2), and seven known compounds were isolated from the methanol extract of Terminalia bellirica leaves, collected in Bangladesh. The structures of the compounds were elucidated using spectroscopic analysis. Among these isolated compounds, corilagin (3) was cytotoxic against human gastric adenocarcinoma cell line AGS at an IC50 of 20.8 mu M, and beta-d-glucopyranose 1,3,6-trigallate (4) exhibited the ability to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance.

Automated summary

Two new compounds were isolated from Terminalia bellirica leaves and their structures were determined. Among them, corilagin exhibited cytotoxicity against gastric cancer cells and beta-d-glucopyranose trigallate showed the ability to overcome TRAIL resistance.