期刊
JOURNAL OF NANOPARTICLE RESEARCH
卷 24, 期 1, 页码 -出版社
SPRINGER
DOI: 10.1007/s11051-022-05397-4
关键词
Mn; Calcium phosphate; Cancer targeting; Drug delivery; MRI; Nanocomposites
资金
- National Natural Science Foundation of China [21373138]
- 111 Innovation and Talent Recruitment Base on Photochemical and Energy Materials [D18020]
- Shanghai Engineering Research Center of Green Energy Chemical Engineering [18DZ2254200]
In this study, we designed Mn-doped calcium phosphate nanoparticles for targeted delivery of anticancer drugs and MR imaging-guided cancer therapy. The nanoparticles showed good biocompatibility and colloidal stability, and exhibited significant targeted therapeutic effect against BxPC-3 cells.
Multifunctional nanoplatform integrated with efficient imaging for diagnosis and therapeutic functions are much promising for realizing highly efficient imaging-guided chemotherapy in vivo but still in a great challenge. The nanocarriers with biodegradable and good biocompatibility are an urgent requirement. Herein, we designed Mn-doped calcium phosphate nanoparticles (Mn-CaPNPs) for targeted delivery of doxorubicin (DOX) and MR imaging-guided cancer therapy. Mn-CaPNPs were synthesized via a double reverse emulsion approach. To obtain excellent colloidal stability, mPEG-NH2 was conjugated to Mn-CaPNPs by electrostatic adsorption. Doxorubicin hydrochloride (DOX) and EGFR Mab C225 were conjugated to the Mn-CaPNPs-mPEG-NH2 via hydrophobic interaction and the cross-linking reaction of glutaraldehyde (Mn-CaPNPs-DOX, Mn-CaPNPs-DOX-Mab C225). The as-prepared multifunctional nanocarrier nanoplatform possess good biocompatibility, high loading capacity for DOX, good T1-MR contrast effect, and significantly enhancing the targeted therapeutic effect against BxPC-3 cells. The results suggested that Mn-CaPNPs could be used as a promising nanocarrier nanoplatform for highly efficient imaging-guided cancer therapy.
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