DNA-binding,-cleavage and antimicrobial investigation on mononuclear Cu(II) Schiff base complexes originated from Riluzole

Two mononuclear metal complexes, [Cu(L-1)(2)] (1) and [Cu(L-2)(2)] (2) of the respective Schiffbases, HL 1 = 2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-4-methoxyphenol and HL2 = 2-((E)(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-4,6-dibromophenol were synthesized and well characterized by analytical and various spectroscopic techniques like elemental analysis, NMR, mass spectrometry, IR, UV, ESR and thermogravimetric analyses. These spectral studies gave a square planar geometry for both the complexes. These complexes underwent DNA investigation against calf thymus DNA and supercoiled pBR322 DNA. The complexes bound the DNA through an intercalation mode and the binding affinity order follows as 1 > 2 > HL 2 > HL1. Both complexes show good cleavage ability against doublestranded pBR322 DNA under oxidative and photolytic conditions. In vitro antimicrobial study resulted in both complexes have shown marked biocidal potential compared to respective free ligands. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

The two mononuclear metal complexes bind to DNA through an intercalation mode and exhibit good cleavage ability under oxidative and photolytic conditions. Both complexes show marked biocidal potential in vitro.