Binding of periodate by non-covalent interaction: Synthesis, characterization, single crystal structure determination, antibacterial and anticancer studies of [Co(bpy)2CO3]•IO4

The facile and effective synthesis of novel cobalt (III) complex salt of composition [Co(bpy)(2)CO3](center dot)IO4 (where bpy=2,2'-bipyridine, IO4=periodate) was performed in aqueous medium at room temperature. The complex was characterized with wide range of analytical and spectroscopic tools such as CHN, FT-IR, UV-Vis and H-1 NMR. The complex salt crystallizes in triclinic space group (P-1) with a = 7.17687(12), b = 10.8056(2), c = 14.3822(3) angstrom, alpha = 83.4356(17)degrees, beta = 85.3108(15)degrees, gamma = 86.2535(16)degrees, V = 1102.56(4) angstrom(3) and Z = 2. The single-crystal X-ray diffraction studies revealed that the complex is six coordinated with the inner coordination sphere of the metal ion comprising of one carbonate and two 2,2'-bipyridine moieties. The crystal has distorted octahedral geometry with hydrogen bonding interactions [C-H delta+center dot center dot center dot O-anion(delta-)] existing in the crystal lattice. The thermogravimetric studies were performed to further support the coordination structure of the complex. In addition, the complex was tested for in vitro antibacterial activity against Gram-positive (S . aureus) and Gram-negative bacteria (E.coli and P. aeruginosa). The complex showed sig-nificant activity against all three bacteria tested, however S. aureus was found to be more sensitive to it, with MIC of 400 mu M. Further, the complex showed good anti-cancer potential as it was able to reduce the viability of HeLa cells in a concentration dependent manner with IC50 value corresponding to 60 mu M. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

A novel cobalt (III) complex salt [Co(bpy)(2)CO3](center dot)IO4 was synthesized in aqueous medium at room temperature and characterized using various analytical techniques. The complex exhibited significant antibacterial activity against Gram-positive and Gram-negative bacteria, as well as promising anti-cancer potential based on its ability to reduce the viability of HeLa cells in a concentration-dependent manner.