The vasculature niches required for hematopoiesis

Endothelial cells play a critical role in supporting postnatal hematopoiesis in the bone marrow. Unique endothelial cells, together with various perivascular cells, form different types of vascular structures, constructing a vast microvascular delivery and trafficking network for blood cells, oxygen, and nutrition. These blood vessels build distinct hematopoietic stem and progenitor cell niches, which offer not only sites of residence for blood cells but also indispensable signals directing HSPC homing, self-renewal, and multilineage differentiation. Deep insight into the structure and function of the BM vasculature niche and its participation in hematopoiesis is necessary to develop advanced strategies for the reconstitution of hematopoiesis.

Automated summary

Endothelial cells and perivascular cells together form a diverse network of blood vessels in the bone marrow, facilitating the delivery of blood cells, oxygen, and nutrients. These vessels create niches for hematopoietic stem and progenitor cells, providing signals for cell homing, self-renewal, and differentiation. Understanding the structure and function of the bone marrow vasculature niche is essential for developing advanced strategies in hematopoiesis reconstitution.