A comprehensive review on nanoemulsion as an ophthalmic drug delivery system

Nanoemulsions formulated for the ocular drug delivery have a good scope in pharmaceutical products due to the transparency at enlarged droplet volume fraction, advanced rate of bioavailability and improved shelf life. They are a part of multiphase colloidal dispersion where a heterogeneous system has fine oil in water or water in oil dispersion in addition with the surfactant and co-surfactant containing droplets within the size range of 20-600 nm and showing a narrow size distribution. This review describes the preparation, characteristics, evaluation and application of nanoemulsions as a drug delivery tool for medication delivery in eyes. The review summarizes in-depth information on the development of ophthalmic nanoemulsions providing sustained release and prolonged therapeutic effect. Various methods comprising of high energy techniques and low energy techniques are discussed in detail. Finally, the techniques for characterization, in-vivo evaluation and applications are deliberated in short. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Nanoemulsions formulated for ocular drug delivery have advantages in terms of transparency, advanced bioavailability, and improved shelf life. They are part of a multiphase colloidal dispersion system with droplets in the size range of 20-600 nm. This review provides detailed information on their preparation, characteristics, evaluation, and applications for sustained release and prolonged therapeutic effect in ophthalmic drug delivery.