期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 339, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molliq.2021.117037
关键词
Curcumin; Deep eutectic solvent; Microemulsion; Surfactant
资金
- Science & Engineering Research Board (SERB), Government of India [PDF/2019/001024]
The solubility and stability of curcumin have been significantly improved in novel water-in-oil microemulsions, making it a promising candidate for clinical applications.
Clinical application of curcumin, a phytochemical with diverse biological activities, are restricted by its low solubility and poor stability. Herein, we report exceptionally high solubility (up to 51 mg/mL under ambient conditions) and significantly improved stability (against sunlight and long-term storage) of curcumin in novel water-in-oil microemulsions formed using a non-ionic surfactant Triton X-100 and a hydrophobic deep eutectic solvent constituted of tetra-n-butylammonium chloride and n-decanoic acid in 1 : 2 mol ratio as the bulk oil phase. (C) 2021 Elsevier B.V. All rights reserved.
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