The AlphaFold Database of Protein Structures: A Biologist's Guide

AlphaFold, the deep learning algorithm developed by DeepMind, recently released the three-dimensional models of the whole human proteome to the scientific community. Here we discuss the advantages, limitations and the still unsolved challenges of the AlphaFold models from the perspective of a biologist, who may not be an expert in structural biology. (C) 2021 The Authors. Published by Elsevier Ltd.

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AlphaFold, a deep learning algorithm developed by DeepMind, recently released three-dimensional models of the entire human proteome to the scientific community. In this discussion, we explore the advantages, limitations, and unresolved challenges of the AlphaFold models from the perspective of a biologist.