Pyroptosis-Induced Inflammation and Tissue Damage

Programmed cell deaths are pathways involving cells playing an active role in their own destruction. Depending on the signaling system of the process, programmed cell death can be divided into two categories, pro-inflammatory and non-inflammatory. Pyroptosis is a pro-inflammatory form of programmed cell death. Upon cell death, a plethora of cytokines are released and trigger a cascade of responses from the neighboring cells. The pyroptosis process is a double-edged sword, could be both beneficial and detrimental in various inflammatory disorders and disease conditions. A physiological outcome of these responses is tissue damage, and sometimes death of the host. In this review, we focus on the inflammatory response triggered by pyroptosis, and resulting tissue damage in selected organs. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

Programmed cell death involves cells actively participating in their own destruction. It can be categorized into pro-inflammatory and non-inflammatory types, with pyroptosis being a pro-inflammatory form. Pyroptosis releases cytokines upon cell death, triggering responses from neighboring cells. It can have both beneficial and detrimental effects in inflammatory disorders and diseases, often resulting in tissue damage. This review focuses on the inflammatory response and tissue damage caused by pyroptosis in selected organs.