4.7 Article

Characterization of Sequence-Specific Binding of LARP6 to the 5' Stem-Loop of Type I Collagen mRNAs and Implications for Rational Design of Antifibrotic Drugs

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Summary: Fibrosis is a major medical issue caused by excessive synthesis of the extracellular matrix, primarily composed of type I collagen. The discovery of a lead compound specifically inhibiting the secretion of type I collagen represents a promising candidate for the development of specific antifibrotic drugs. Targeting the master regulator LARP6, which plays a crucial role in the translation of collagen mRNA, could provide a novel approach for treating fibrosis.

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