Nanodesigning of multifunctional quantum dots and nanoparticles for the treatment of fibrosarcoma

An effective, dual drug(DD) loaded nanocarrier system (nano particle(NP), quantum dots(QDs)) having two active substances was aimed to develop for the treatment of fibrosarcoma. Zinc oxide(ZnO) QDs were produced using zinc acetate dehydrate as a precursor, were incorporated with chitosan(Ch), and finally decorated with PEG-linked folic acid and were found to be effective after imatinib mesylate(IM) and dexketoprofen trometamol(DT) were loaded. Characterisations, in vitro drug releases, cell toxicities, penetrations through cell lines and in-vivo animal tests of the prepared nanosystems were performed. The size of hybrid nanoparticles were 168.6 +/- 48.8 nm, surface charge was -35.8 +/- 0.26 mV. The encapsulation efficiency was 75% for IM and 99% for DT. DD-functionalised QDChNPs and lyophilised functionalised QDChNPs in capsules slowed down tumour growth by up to 76.5 and 88.7%. Our results demonstrate that developed hybrid nanoparticles are highly effective. This hybrid system gathers many of the advantages of nanotechnology into one form.

Automated summary

An effective, dual-drug loaded nanocarrier system was developed for the treatment of fibrosarcoma. The hybrid nanoparticles, composed of zinc oxide quantum dots and chitosan, decorated with PEG-linked folic acid, demonstrated high efficacy after loading imatinib mesylate and dexketoprofen trometamol. The prepared nanosystems were characterized and evaluated in vitro and in vivo, showing promising results in tumor growth inhibition.