期刊
JOURNAL OF MICROBIOLOGY
卷 60, 期 1, 页码 128-136出版社
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-022-1620-3
关键词
Acinetobacter baumannii; antimicrobial peptide; gold nanoparticle; multidrug-resistant bacteria
类别
资金
- Chung-Ang University Graduate Research Scholarship
- National Research Foundation of Korea [NRF-2021R1A2C3008934, NRF-2021R1-I1A1A01056162]
- National Research Foundation of Korea [4199990314086] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study demonstrates that AuNP-Apt loaded with Lys AB2 P3-His can effectively inhibit Acinetobacter baumannii infection in mice, leading to increased survival.
Acinetobacter baumannii causes multidrug resistance, leading to fatal infections in humans. In this study, we showed that Lys AB2 P3-His-a hexahistidine-tagged form of an antimicrobial peptide (AMP) loaded onto DNA aptamer-functionalized gold nanoparticles (AuNP-Apt)-can effectively inhibit A. baumannii infection in mice. When A. baumannii-infected mice were intraperitoneally injected with AuNP-Apt loaded with Lys AB2 P3-His, a marked reduction in A. baumannii colonization was observed in the mouse organs, leading to prominently increased survival time and rate of the mice compared to those of the control mice treated with AuNP-Apt or Lys AB2 P3-His only. This study shows that AMPs loaded onto AuNP-Apt could be an effective therapeutic tool against infections caused by multidrug-resistant pathogenic bacteria in humans.
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