期刊
JOURNAL OF MICROBIOLOGY
卷 60, 期 3, 页码 290-299出版社
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-022-1525-1
关键词
SARS-CoV-2; COVID-19; interferon; immunity
类别
资金
- Basic Science Research Program of the National Research Foundation of Korea (NRF) by the Ministry of Science, ICT & Future Planning [NRF-2019R1A2C1005961]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI21C1252]
This article summarizes the innate immune sensing mechanisms of SARS-CoV-2 and strategies used by the virus to evade antiviral immune signaling pathways in the host. Understanding these mechanisms is crucial for the improvement of vaccines and therapeutic strategies.
With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.
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