期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 65, 期 1, 页码 424-435出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.1c01591
关键词
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资金
- Natural Science Foundation Committee of China [NSFC 82001981]
- Postdoctoral Innovative Talent Support Program [BX20190389]
- China Postdoctoral Science Foundation [2019M662009]
- Postdoctoral Research Grant of Jiangsu Province
Light-triggered NO donors can accelerate the migration and proliferation of endothelial cells, leading to angiogenesis. NO donors in combination with Levofloxacin show synergistic effects in eradicating MRSA biofilms and treating bacteria-infected wounds.
Nitric oxide (NO) has an important class of endogenous diatomic molecules that play a key regulatory role in many physiological and biochemical processes. However, the type of nitrosamine NO donor stimulated by light has many advantages compared to the conventional NO donors such as diazeniumdiolates and S-nitrosothiols compounds, including easy synthesis, good stability, and controllable release. In addition, NO release can be regulated by light induction with a built-in calibration mechanism fluorescence. Here, we report that the migration and proliferation of human umbilical vein vascular endothelial cells could be accelerated by the light-triggered NO donors, leading to the angiogenesis. Meanwhile, the screened NO donor 3a with Levofloxacin (Lev) showed synergistic effects to eradicate Methicillin-resistant Staphylococcus aureus (MRSA) biofilms in vitro and treat bacteria-infected wound in vivo.
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