4.7 Editorial Material

New Heights for ProTides?

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Article Chemistry, Medicinal

Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties

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Summary: This study describes the discovery of novel prodrugs using tyrosine derivatives that effectively inhibit HIV-1 and HBV viruses with high selectivity index. Metabolic studies demonstrate higher cellular uptake and release of tenofovir compared to FDA-approved tenofovir alafenamide fumarate (TAF).

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs

A Siddiqui et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)