相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms
Channa Bao et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)
Protein kinase inhibitors for amyotrophic lateral sclerosis therapy
Valle Palomo et al.
BRITISH JOURNAL OF PHARMACOLOGY (2021)
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral
Elisa Rojas-Prats et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo
Tamara Halkina et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis
Loreto Martinez-Gonzalez et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Trends in kinase drug discovery: targets, indications and inhibitor design
Misty M. Attwood et al.
NATURE REVIEWS DRUG DISCOVERY (2021)
TDP-43 proteinopathies: a new wave of neurodegenerative diseases
Eva Maria Johanna de Boer et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor
Douglas J. Marcotte et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2020)
Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites
Gregory M. Dillon et al.
PLOS ONE (2020)
Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment
Loreto Martinez-Gonzalez et al.
SCIENTIFIC REPORTS (2020)
DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity
Martin Schroeder et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
Terry R. Suk et al.
MOLECULAR NEURODEGENERATION (2020)
Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients
Diana Posa et al.
MOLECULAR NEUROBIOLOGY (2019)
Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species
Mirta Boban et al.
JOURNAL OF NEUROSCIENCE METHODS (2019)
OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules
Katarina Roos et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2019)
Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Henriette Haukedal et al.
JOURNAL OF MOLECULAR BIOLOGY (2019)
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
Archana Prasad et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)
Tau tubulin kinases in proteinopathy
Laura M. Taylors et al.
FEBS JOURNAL (2019)
Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases
Vanesa Nozal et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis
Valle Palomo et al.
ACS CHEMICAL NEUROSCIENCE (2019)
TDP43 and RNA instability in amyotrophic lateral sclerosis
Kaitlin Weskamp et al.
BRAIN RESEARCH (2018)
Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function
Wen Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Efficient and reliable establishment of lymphoblastoid cell lines by Epstein-Barr virus transformation from a limited amount of peripheral blood
Natsue Omi et al.
SCIENTIFIC REPORTS (2017)
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
Yu Tang et al.
MOLECULAR NEUROBIOLOGY (2016)
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia
Carolina Alquezar et al.
MOLECULAR NEURODEGENERATION (2016)
TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets
Emma L. Scotter et al.
NEUROTHERAPEUTICS (2015)
Lewis Acid-Catalyzed Generation of C-C and C-N Bonds on π-Deficient Heterocyclic Substrates
Matteo Staderini et al.
ADVANCED SYNTHESIS & CATALYSIS (2015)
The El Escorial criteria: Strengths and weaknesses
Federica Agosta et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2015)
Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole
Lukas Cajanek et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43
Nicole F. Liachko et al.
PLOS GENETICS (2014)
The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor
Susan E. Kiefer et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2014)
How good are my data and what is the resolution?
Philip R. Evans et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)
CDC7 Inhibition Blocks Pathological TDP-43 Phosphorylation and Neurodegeneration
Nicole F. Liachko et al.
ANNALS OF NEUROLOGY (2013)
Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain
Harald Lund et al.
BRAIN PATHOLOGY (2013)
X-ray Structural Analysis of Tau-Tubulin Kinase 1 and Its Interactions with Small Molecular Inhibitors
Yafeng Xue et al.
CHEMMEDCHEM (2013)
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
G. Madhavi Sastry et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress
Diane Moujalled et al.
PLOS ONE (2013)
TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias
Peter K. Jackson
CELL (2012)
Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies
Yohei Iguchi et al.
NEUROBIOLOGY OF DISEASE (2012)
Integration, scaling, space-group assignment and post-refinement
Wolfgang Kabsch
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Analysis of Kinase Inhibitor Selectivity using a Thermodynamics-Based Partition Index
Alan C. Cheng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Identification of casein kinase-1 phosphorylation sites on TDP-43
Fuyuki Kametani et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
Iga Wegorzewska et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The selectivity of protein kinase inhibitors: a further update
Jenny Bain et al.
BIOCHEMICAL JOURNAL (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
Richard A. Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation
Shinji Sato et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the aurora kinase inhibitor VX-680
MA Young et al.
CANCER RESEARCH (2006)
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
RA Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Glide: A new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening
TA Halgren et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
High throughput artificial membrane permeability assay for blood-brain barrier
L Di et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)
Microglial cells protect cerebellar granule neurons from apoptosis: Evidence for reciprocal signaling
E Polazzi et al.
GLIA (2001)
分享论文
