相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer
Shipeng He et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
Discovery of Thieno[2,3-d]pyrimidine-Based Hydroxamic Acid Derivatives as Bromodomain-Containing Protein 4/Histone Deacetylase Dual Inhibitors Induce Autophagic Cell Death in Colorectal Carcinoma Cells
Zhaoping Pan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy
Tingting Liu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines
Martin Huegle et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds
Ewgenij Proschak et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents
Gaoliang Cheng et al.
BIOORGANIC CHEMISTRY (2019)
Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy
Gloria Manzotti et al.
CANCERS (2019)
Bromodomains: a new target class for drug development
Andrea G. Cochran et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Fluorescent analogs of peptoid-based HDAC inhibitors: Synthesis, biological activity and cellular uptake kinetics
Rick Raudszus et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties
Viktoria Krieger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy
Ali Alqahtani et al.
FUTURE SCIENCE OA (2019)
Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response
Sanil Bhatia et al.
BLOOD (2018)
NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model
Yan Liu et al.
CANCER RESEARCH (2018)
TCFH-NMI: Direct Access to N-Acyl Imidazoliums for Challenging Amide Bond Formations
Gregory L. Beutner et al.
ORGANIC LETTERS (2018)
Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma
Wei Meng et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)
Causes of death among children aged 5-14 years in the WHO European Region: a systematic analysis for the Global Burden of Disease Study 2016
Hmwe H. Kyu et al.
LANCET CHILD & ADOLESCENT HEALTH (2018)
Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma
Jimmy Lee et al.
BLOOD ADVANCES (2018)
c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer
Angela Nebbioso et al.
CLINICAL CANCER RESEARCH (2017)
Histone Deacetylase Inhibitors as Anticancer Drugs
Tomas Eckschlager et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups
Viktoria Krieger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Intramolecular Didehydro-Diels-Alder Reaction for the Synthesis of Benzo-and Dihydrobenzo-Fused Heterocycles
Ashley E. Bober et al.
ORGANIC LETTERS (2017)
Epigenetics in cancer: Fundamentals and Beyond
Subhankar Biswas et al.
PHARMACOLOGY & THERAPEUTICS (2017)
Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer
Dennis O. Adeegbe et al.
CANCER DISCOVERY (2017)
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles
Martin Huegle et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
The promise of epigenetic therapy: reprogramming the cancer epigenome
Andrew D. Kelly et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2017)
Bromodomains: Structure, function and pharmacology of inhibition
Elena Ferri et al.
BIOCHEMICAL PHARMACOLOGY (2016)
Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors
Zhimin Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Inside HDACs with more selective HDAC inhibitors
Joelle Roche et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)
Martin Huegle et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions
Chad A. Brautigam et al.
NATURE PROTOCOLS (2016)
Epigenetic polypharmacology: from combination therapy to multitargeted drugs
Angel R. de Lera et al.
CLINICAL EPIGENETICS (2016)
40-year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971-2011: a population-based study
Manuela Quaresma et al.
LANCET (2015)
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Pawel K. Mazur et al.
NATURE MEDICINE (2015)
Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions
Michael Brand et al.
ACS CHEMICAL BIOLOGY (2015)
HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape
Mariarosaria Conte et al.
ONCOTARGET (2015)
Polypharmacology: the rise of multitarget drugs over combination therapies
Michela Rosini
FUTURE MEDICINAL CHEMISTRY (2014)
Polypharmacology: Challenges and Opportunities in Drug Discovery
Andrew Anighoro et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells
Warren Fiskus et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Targeting bromodomains: epigenetic readers of lysine acetylation
Panagis Filippakopoulos et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Bulk-solvent and overall scaling revisited: faster calculations, improved results
P. V. Afonine et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2013)
4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading
Xavier Lucas et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Towards automated crystallographic structure refinement with phenix.refine
Pavel V. Afonine et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)
High-Precision Isothermal Titration Calorimetry with Automated Peak-Shape Analysis
Sandro Keller et al.
ANALYTICAL CHEMISTRY (2012)
Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007
Graca M. Dores et al.
BLOOD (2012)
Outcomes after Induction Failure in Childhood Acute Lymphoblastic Leukemia
Martin Schrappe et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
An introduction to data reduction: space-group determination, scaling and intensity statistics
Philip R. Evans
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2011)
MolProbity: all-atom structure validation for macromolecular crystallography
Vincent B. Chen et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
XDS
Wolfgang Kabsch
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Targeting histone deacetyalses in the treatment of B- and T-cell malignancies
Jasmine Zain et al.
INVESTIGATIONAL NEW DRUGS (2010)
Automatic multiple-zone rigid-body refinement with a large convergence radius
Pavel V. Afonine et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2009)
A Short Synthesis of Enantiomeric Phytoprostanes B1 Type I
Wieslawa Perlikowska et al.
SYNTHESIS-STUTTGART (2009)
Synthesis of N-(2,8-Dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yl) Acetamide and Benzamide
Guy L. Plourde et al.
MOLBANK (2009)
Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer
B. Sadikovic et al.
CURRENT GENOMICS (2008)
Short, Efficient Syntheses of Pyrrole -Amides
Michael T. Huggins et al.
SYNTHETIC COMMUNICATIONS (2008)
Synthesis and biological evaluation of phosphate Prodrugs of 4-Phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase
Gian Filippo Ruda et al.
CHEMMEDCHEM (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
The mammalian epigenome
Bradley E. Bernstein et al.
CELL (2007)
Scaling and assessment of data quality
P Evans
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)
Ru-catalyzed alkene-alkyne coupling. Total synthesis of amphidinolide P
BM Trost et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
In vivo drug discovery in the zebrafish
LI Zon et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Regioselective syntheses of 2,3,4-tribromopyrrole and 2,3,5-tribromopyrrole
EA John et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases
B Heitweg et al.
ANALYTICAL BIOCHEMISTRY (2003)
The fundamental role of epigenetic events in cancer
PA Jones et al.
NATURE REVIEWS GENETICS (2002)
New methods for side-chain protection of cysteine
CW West et al.
ORGANIC LETTERS (2001)
The language of covalent histone modifications
BD Strahl et al.
NATURE (2000)