4.7 Article

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Talazoparib: First Global Approval

Sheridan M. Hoy

Article Chemistry, Medicinal

Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors

Ann-Gerd Thorsell et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Genetics & Heredity

Synthetic lethality and cancer

Nigel J. O'Neil et al.

NATURE REVIEWS GENETICS (2017)

Review Multidisciplinary Sciences

PARP inhibitors: Synthetic lethality in the clinic

Christopher J. Lord et al.

SCIENCE (2017)

Article Pharmacology & Pharmacy

Neuroprotective effects of a novel poly (ADP-ribose) polymerase-1 inhibitor, JPI-289, in hypoxic rat cortical neurons

Youngchul Kim et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2017)

Editorial Material Oncology

PARP inhibitors: the race is on

Jessica S. Brown et al.

BRITISH JOURNAL OF CANCER (2016)

Article Chemistry, Medicinal

An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy

Ying-Qing Wang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Cell Biology

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

Yves Pommier et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Article Chemistry, Medicinal

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

Jeffrey W. Johannes et al.

ACS MEDICINAL CHEMISTRY LETTERS (2015)

Article Chemistry, Medicinal

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors

Anthony R. Gangloff et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Biochemistry & Molecular Biology

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

Marie-France Langelier et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

PARP inhibitors: polypharmacology versus selective inhibition

Torun Ekblad et al.

FEBS JOURNAL (2013)

Review Oncology

Structural implications for selective targeting of PARPs

Jamin D. Steffen et al.

FRONTIERS IN ONCOLOGY (2013)

Article Biochemistry & Molecular Biology

Genetic Interactions in Cancer Progression and Treatment

Alan Ashworth et al.

Article Chemistry, Medicinal

Evolution of Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors. From Concept to Clinic

Dana V. Ferraris

JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Biotechnology & Applied Microbiology

The influence of drug-like concepts on decision-making in medicinal chemistry

Paul D. Leeson et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Article Chemistry, Medicinal

Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase

Kouji Hattori et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Article Chemistry, Medicinal

4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors

J Ishida et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Multidisciplinary Sciences

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

H Farmer et al.

NATURE (2005)