相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor
Marina Buyanova et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
Brian A. Lanman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
Jay B. Fell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Drugging all RAS isoforms with one pocket
Dirk Kessler et al.
FUTURE MEDICINAL CHEMISTRY (2020)
Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics
Hao Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo
Kotaro Sakamoto et al.
SCIENTIFIC REPORTS (2020)
Drugging an undruggable pocket on KRAS
Dirk Kessler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
Jude Canon et al.
NATURE (2019)
The reactivity-driven biochemical mechanism of covalent KRAS(G12C) inhibitors
Rasmus Hansen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
The reactivity-driven biochemical mechanism of covalent KRAS(G12C) inhibitors
Rasmus Hansen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines
Sebastien L. Degorce et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Salt Bridge in Ligand-Protein Complexes-Systematic Theoretical and Statistical Investigations
Rafal Kurczab et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2018)
Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity
Jay B. Fell et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d
Satoshi Sogabe et al.
ACS MEDICINAL CHEMISTRY LETTERS (2017)
Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis
Simone Keller et al.
BMC CANCER (2017)
Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes
Lynn M. McGregor et al.
BIOCHEMISTRY (2017)
RAS Proteins and Their Regulators in Human Disease
Dhirendra K. Simanshu et al.
CELL (2017)
Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging
Ayumu Niida et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology
Kotaro Sakamoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere
Rainer Wilcken et al.
ACS CHEMICAL BIOLOGY (2015)
Inhibition of Ras Signaling by Blocking Ras-Effector Interactions with Cyclic Peptides
Punit Upadhyaya et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Conformational restriction: an effective tactic in 'follow-on'-based drug discovery
Zengjun Fang et al.
FUTURE MEDICINAL CHEMISTRY (2014)
Drugging the undruggable RAS: Mission Possible?
Adrienne D. Cox et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Inhibition of Ras-effector interactions by cyclic peptides
Xianghong Wu et al.
MEDCHEMCOMM (2013)
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation
Qi Sun et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
A Comprehensive Survey of Ras Mutations in Cancer
Ian A. Prior et al.
CANCER RESEARCH (2012)
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Till Maurer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Strong and weak hydrogen bonds in the protein-ligand interface
Sunil K. Panigrahi et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)
The role and significance of unconventional hydrogen bonds in small molecule recognition by biological receptors of pharmaceutical relevance
Gergely Toth et al.
CURRENT PHARMACEUTICAL DESIGN (2007)
The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity
S Hanessian et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
分享论文
