4.7 Article

Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Fragments: where are we now?

James Osborne et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2020)

Article Immunology

PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling

Yukinori Tanaka et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

PRMT5 is essential for B cell development and germinal center dynamics

Ludivine C. Litzler et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Francisco Sanchez-Vega et al.

Article Chemistry, Medicinal

Determination of Affinity and Residence Time of Potent Drug-Target Complexes by Label-free Biosensing

John G. Quinn et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity

Zahid Q. Bonday et al.

ACS MEDICINAL CHEMISTRY LETTERS (2018)

Article Chemistry, Medicinal

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

Kenneth W. Duncan et al.

ACS MEDICINAL CHEMISTRY LETTERS (2016)

Article Multidisciplinary Sciences

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis et al.

SCIENCE (2016)

Article Biochemical Research Methods

An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery

Pawel Linke et al.

JOURNAL OF BIOMOLECULAR SCREENING (2016)

Article Biochemistry & Molecular Biology

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Elayne Chan-Penebre et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Multidisciplinary Sciences

Prmt5 is required for germ cell survival during spermatogenesis in mice

Yanbo Wang et al.

SCIENTIFIC REPORTS (2015)

Article Chemistry, Organic

Preparation and Reactions of Heteroarylmethylzinc Reagents

Nadja M. Barl et al.

ORGANIC LETTERS (2014)

News Item Biotechnology & Applied Microbiology

Fragment-based lead discovery grows up

Monya Baker

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Multidisciplinary Sciences

Crystal structure of the human PRMT5:MEP50 complex

Stephen Antonysamy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Chemistry, Medicinal

Revealing Atropisomer Axial Chirality in Drug Discovery

Steven R. LaPlante et al.

CHEMMEDCHEM (2011)

Review Pharmacology & Pharmacy

Fragment screening to predict druggability (ligandability) and lead discovery success

Fredrik N. B. Edfeldt et al.

DRUG DISCOVERY TODAY (2011)

Article Biochemistry & Molecular Biology

Biosensor-based small molecule fragment screening with biolayer interferometry

Charles A. Wartchow et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2011)

Article Chemistry, Medicinal

Assessing Atropisomer Axial Chirality in Drug Discovery and Development

Steven R. LaPlante et al.

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Protein Arginine Methyltransferase 5 Regulates ERK1/2 Signal Transduction Amplitude and Cell Fate Through CRAF

Pedro Andreu-Perez et al.

SCIENCE SIGNALING (2011)

Review Biochemistry & Molecular Biology

Versatility of PRMT5-induced methylation in growth control and development

Vrajesh Karkhanis et al.

TRENDS IN BIOCHEMICAL SCIENCES (2011)

Article Chemistry, Medicinal

Using the Golden Triangle to optimize clearance and oral absorption

Ted W. Johnson et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Review Biochemistry & Molecular Biology

Protein Arginine Methylation in Mammals: Who, What, and Why

Mark T. Bedford et al.

MOLECULAR CELL (2009)

Article Chemistry, Medicinal

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Article Biotechnology & Applied Microbiology

The influence of drug-like concepts on decision-making in medicinal chemistry

Paul D. Leeson et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Review Pharmacology & Pharmacy

Fragment-based lead discovery: leads by design

RAE Carr et al.

DRUG DISCOVERY TODAY (2005)

Article Biochemistry & Molecular Biology

A novel WD repeat protein component of the methylosome binds Sm proteins

WJ Friesen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins

WJ Friesen et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Pharmacology & Pharmacy

Synthesis and characterisation of a new class of stable S-adenosyl-L-methionine salts

A Morana et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2000)