Facile Synthesis of Deuterium-Labelled Geranylgeraniols

Facile and stereoselective syntheses of three different kinds of deuterium-labelled geranylgeraniol analogs have been achieved. LiAlD4 is used as the deuterium source to ensure high deuterium incorporation. [8,8-d(2)]- and [9,9-d(2)]-geranylgeraniols have been prepared for the first time. [10-d]-geranylgeraniol was efficiently prepared with a high degree of deuterium incorporation.