期刊
JOURNAL OF MEDICAL VIROLOGY
卷 94, 期 2, 页码 549-556出版社
WILEY
DOI: 10.1002/jmv.27431
关键词
G protein; human respiratory syncytial virus (HRSV); phylogenetic analysis
类别
资金
- KCDC
- Bioefficacy Research Center at Myongji University
Investigation of human respiratory syncytial virus (HRSV) in Gyeonggi Province from 2015/16 to 2017/18 revealed HRSV-B predominance with the exception of the 2016/17 season where HRSV-A was dominant. The highest prevalence of HRSV was seen in patients aged 0-2 years, with common symptoms including fever, nasal obstruction, and wheezing. Phylogenetic analysis showed that HRSV-A patients had the ON1 genotype, while HRSV-B patients had the BA9 genotype.
To investigate the molecular characteristics of human respiratory syncytial virus (HRSV) detected in Gyeonggi Province from 2015/16 to 2017/18, 2331 specimens from patients with sporadic acute respiratory illness and 85 specimens from four HRSV outbreaks in the postpartum care center were analyzed by real-time reverse transcription PCR. HRSVs were detected in 97 of the 2416 (4.0%) specimens, and among the positive specimens, 38 (39.2%) were identified as HRSV-A and 59 (60.8%) as HRSV-B. During the study periods, HRSV-B predominated in all seasons, except in 2016/17 during which HRSV-A predominated. Depending on the age groups, HRSV prevalence was the highest in 0- to 2-year-old patients. Comparison of noninfected subjects with HRSV-infected subjects revealed that HRSV infection more frequently resulted in fever, nasal obstruction, and wheezing, although the frequency of sore throat was low; however, comparison of the symptoms between HRSV-A- and HRSV-B-infected patients revealed no significant differences in symptoms. Phylogenetic analysis showed that all HRSV-A patients had an ON1 genotype, and all HRSV-B patients had an BA9 genotype. These results provide a valuable reference regarding the circulating pattern and molecular characterization of HRSV. Continuous monitoring will be essential to detect newly emerging HRSV genotypes.
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