Electrochemical sensing platform based on modified graphite screen-printed electrode to determine isoproterenol in the presence of theophylline and acetaminophen

This paper produced a novel and sensitive electrochemical sensor based on the MoS2 nanosheets modified graphite screen-printed electrode (MoS2 NSS/GSPE) to determine isoproterenol (IP) in the presence of theophylline (TPH) and acetaminophen (AC). Therefore, isoproterenol electrochemical behaviors have been examined by cyclic voltammetry (CV), chronoamperometry (CHA), and differential pulse voltammetry (DPV). Analyses showed that in comparison with the unmodified electrode, MoS2 NSs/GSPE had higher electrocatalytic response that could be attributable to MoS2 NSS conductivity and greater surface areas. Based on the optimal condition, the current response also linearly related to isoproterenol concentration in range between 0.07 and 550.0 mu M with low limit of detection (LOD) equal to 0.03 mu M (S/N = 3). This sensor showed three separate oxidative peaks at 190 mV for isoproterenol and at 390 mV for acetaminophen and at 970 mV for theophylline, which were far from each other enough for simultaneous detection of the three drugs. In addition, analytical function of this new electrochemical sensor has been evaluated to determine isoproterenol, theophylline, and acetaminophen in the isoproterenol injection, the theophylline oral solution, and oral solution of acetaminophen.

Automated summary

This study developed a novel electrochemical sensor based on MoS2 nanosheets modified graphite screen-printed electrode for sensitive detection of isoproterenol in the presence of other compounds. The sensor showed linear response to isoproterenol concentration under optimized conditions with a low detection limit.