期刊
JOURNAL OF MAGNETIC RESONANCE
卷 334, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2021.107122
关键词
Chemical Exchange Saturation Transfer (CEST); Z-spectrum; Peak detection; Noise level; Gaussian process regression; User interface; Python; Tkinter
资金
- French National Research Agency (ANR)
- Deutsche Forschungsgemeinschaft (DFG)
- French Alternatives Energies and Atomic Energy Commission (CEA)
CEST is a powerful metabolic imaging technique, but extracting quantitative information from Z-spectra remains challenging. The PEAKIT tool, as an alternative approach, can help identify CEST peaks and output related information.
Chemical Exchange Saturation Transfer (CEST) is a powerful technique for metabolic imaging, capable of exploring concentrations in the mu M to mM range. However, extracting quantitative information from Z-spectra can be challenging due to the non-CEST contributions present and the limited knowledge about the exchanging pools. The PEAKIT tool is proposed as an alternative approach to quantifying CEST peaks, which requires no prior assumptions about the frequency offset or the underlying shape of the baseline. Specifically, the tool takes as input an experimental Z-spectrum and proceeds to identify peak candidates. After a baseline estimation based on Gaussian Process regression, PEAKIT outputs the chemical shift offsets, the areas, the heights and the statistical significance of the detected peaks. The performance and limitations of the PEAKIT tool are discussed for in vitro and in vivo applications. (C) 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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