期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 111, 期 1, 页码 63-74出版社
WILEY
DOI: 10.1002/JLB.3MIR0221-100R
关键词
calcium modulators; HDT; pCAMKII
资金
- FRQS
- Fonds de Recherche du Quebec en Sante (FRQS)
This article explores the potential of pEVs as valuable biomarkers in disease, with a special focus on their role as predictors of and contributors to COVID-19.
Platelets and platelet extracellular vesicles (pEV) are at the crossroads of coagulation and immunity. Extracellular vesicles are messengers that not only transmit signals between cells, but also provide information about the status of their cell of origin. Thus, pEVs have potential as both biomarkers of platelet activation and contributors to pathology. Coronavirus Disease-19 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a complex disease affecting multiple organs and is characterized by a high degree of inflammation and risk of thrombosis in some patients. In this review, we introduce pEVs as valuable biomarkers in disease with a special focus on their potential as predictors of and contributors to COVID-19.
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